Prosody and scope in German inverse linking constructions

In German, prosody interacts with quantifier scope. We investigate this interaction in inverse linking constructions. We present evidence from elicited production of linguistically naive speakers supporting the following two claims: 1) There are two kinds of inverse linking constructions of which only the prepositional type requires a marked intonation contour for inverse scope. 2) In the prepositional construction, a double focus contour is employed with inverse scope rather that a topic-focus (rise-fall) contour as previously assumed (Krifka 1998)

An Approach to Calculate and Visualize Intraoperative Scattered Radiation Exposure

During the intraoperative radiograph generation process with mobile image intensifier systems (C-arm) most of the radiation exposure for patient, surgeon and operation room personal is caused by scattered radiation. The intensity and propagation of scattered radiation depend on different parameters, e.g. the intensity of the primary radiation, and the positioning of the mobile image intensifier. Exposure through scattered radiation can be minimized when all these parameters are adjusted correctly. Because radiation is potentially dangerous and could not be perceived by any human sense the current education on correct adjustment of a C-arm is designed very theoretical. This paper presents an approach of scattered radiation calculation and visualization embedded in a computer based training system for mobile image intensifier systems called virtX. With the help of this extension the virtX training system should enrich the current radiation protection training with visual and practical training aspects

Using openEHR Archetypes for Automated Extraction of Numerical Information from Clinical Narratives

Up to 80% of medical information is documented by unstructured data such as clinical reports written in natural language. Such data is called unstructured because the information it contains cannot be retrieved automatically as straightforward as from structured data. However, we assume that the use of this flexible kind of documentation will remain a substantial part of a patient’s medical record, so that clinical information systems have to deal appropriately with this type of information description. On the other hand, there are efforts to achieve semantic interoperability between clinical application systems through information modelling concepts like HL7 FHIR or openEHR. Considering this, we propose an approach to transform unstructured documented information into openEHR archetypes. Furthermore, we aim to support the field of clinical text mining by recognizing and publishing the connections between openEHR archetypes and heterogeneous phrasings. We have evaluated our method by extracting the values to three openEHR archetypes from unstructured documents in English and German language

The INCA System: A Further Step Towards a Telemedical Artificial Pancreas

Biomedical engineering research efforts have accomplished another level of a ldquotechnological solutionrdquo for diabetes: an artificial pancreas to be used by patients and supervised by healthcare professionals at any time and place. Reliability of continuous glucose monitoring, availability of real-time programmable insulin pumps, and validation of safe and efficient control algorithms are critical components for achieving that goal. Nevertheless, the development and integration of these new technologies within a telemedicine system can be the basis of a future artificial pancreas. This paper introduces the concept, design, and evaluation of the ldquointelligent control assistant for diabetes, INCArdquo system. INCA is a personal digital assistant (PDA)-based personal smart assistant to provide patients with closed-loop control strategies (personal and remote loop), based on a real-time continuous glucose sensor (Guardian RT, Medtronic), an insulin pump (D-TRON, Disetronic Medical Systems), and a mobile general packet radio service (GPRS)-based telemedicine communication system. Patient therapeutic decision making is supervised by doctors through a multiaccess telemedicine central server that provides to diabetics and doctors a Web-based access to continuous glucose monitoring and insulin infusion data. The INCA system has been technically and clinically evaluated in two randomized and crossover clinical trials showing an improvement on glycaemic control of diabetic patients

project report Promise2007

Das Projekt Promise2007 befasste sich mit der Erstellung und Auswertung einer Statistik zur Mitgliedersituation im Berufsverband Medizinischer Informatiker e.V.. Mit dem Ziel mehr über die Mitglieder und ihre derzeitige Situation zu erfahren wurde das Projekt an der Fachhochschule Hannover initiiert. Statistisch erfasst wurden Fragen zum Beschäftigungsverhältnis, zu Aus- und Weiterbildung, der beruflichen Situation und persönliche Angaben. Die Ergebnisse wurden ausgewertet und daraus wichtige Erkenntnisse für den BVMI e.V. abgeleitet, welche auf die weitere Verbandsarbeit Einfluss nehmen

Contemporary update of cancer control after radical prostatectomy in the UK

Despite a significant increase of the number of radical prostatectomies (RPs) to treat organ-confined prostate cancer, there is very limited documentation of its oncological outcome in the UK. Pathological stage distribution and changes of outcome have not been audited on a consistent basis. We present the results of a multicentre review of postoperative predictive variables and prostatic-specific antigen (PSA) recurrence after RP for clinically organ-confined disease. In all, 854 patient's notes were audited for staging parameters and follow-up data obtained. Patients with neoadjuvant and adjuvant treatment as well as patients with incomplete data and follow-up were excluded. Median follow-up was 52 months for the remaining 705 patients. The median PSA was 10 ng ml−1. A large migration towards lower PSA and stage was seen. This translated into improved PSA survival rates. Overall Kaplan–Meier PSA recurrence-free survival probability at 1, 3, 5 and 8 years was 0.83, 0.69, 0.60 and 0.48, respectively. The 5-year PSA recurrence-free survival probability for PSA ranges 20 ng ml−1 was 0.82, 0.73, 0.59 and 0.20, respectively (log rank, P<0.0001). PSA recurrence-free survival probabilities for pathological Gleason grade 2–4, 5 and 6, 7 and 8–10 at 5 years were 0.84, 0.66, 0.55 and 0.21, respectively (log rank, P<0.0001). Similarly, 5-year PSA recurrence-free survival probabilities for pathological stages T2a, T2b, T3a, T3b and T4 were 0.82, 0.78, 0.48, 0.23 and 0.12, respectively (log rank, P=0.0012). Oncological outcome after RP has improved over time in the UK. PSA recurrence-free survival estimates are less optimistic compared to quoted survival figures in the literature. Survival figures based on pathological stage and Gleason grade may serve to counsel patients postoperatively and to stratify patients better for adjuvant treatment

Global crustal stress pattern based on the world stress map database release 2008

The World Stress Map (WSM) project is a global compilation of information on the contemporary crustal stress field from a wide range of stress indicators. The WSM database release 2008 contains 21,750 stress data records that are quality-ranked using an updated and refined quality-ranking scheme. Almost 17,000 of these data records have A–C quality and are considered to record the orientation of maximum horizontal compressional stress SH to within ±25°. As this is almost a triplication of data records compared with the first WSM database release in 1992, we reinvestigate the spatial wave-length of the stress patterns with a statistical analysis on a global 0.5° grid. The resulting smoothed global stress map displays both; the mean SH orientation that follows from the maximum smoothing radius for which the standard deviation is 2000 km) exist for example in North America and NE Asia. These have been used in earlier analyses to conclude that the global stress pattern is primarily controlled by plate boundary forces that are transmitted into the intraplate region. However, our analysis reveals that rather short wave-length of the stress pattern <200 km are quite frequent too, particularly in western Europe, Alaska and the Aleutians, the southern Rocky Mountains, Basin and Range province, Scandinavia, Caucasus, most of the Himalayas and Indonesia. This implies that local stress sources such as density contrasts and active fault systems in some areas have high impact in comparison to plate boundary forces and control the regional stress pattern

Professionalisierung der Beratung zum Einsatz digitaler Medien in der Lehre. Das Weiterbildungskonzept "Hochschuldidaktische Beratung"

Im Rahmen des Bund-Länder-Programms für bessere Studienbedingungen und mehr Qualität in der Lehre ("Qualitätspakt Lehre") verfolgt das Verbundprojekt eCULT das Ziel, vorhandene Erfahrungen im Einsatz digitaler Lerntechnologien aufzugreifen und in die Breite zu tragen. Um Lehrende möglichst gut auf den Einsatz von digitalen Medien vorbereiten zu können und sie didaktisch zu unterstützen, bedarf es einer Professionalisierung der vorhandenen Support- und Beratungsstrukturen – und damit der hochschuldidaktischen Beratung. Dieses äußerst anspruchsvolle Tätigkeitsfeld mit seinen vielfältigen Anforderungen ist Gegenstand eines Qualifizierungsangebotes für didaktische Beraterinnen und Berater in Hochschulen. Die hochschulzertifizierte Weiterbildung hat einen Umfang von 30 Credit Points und umfasst neun Module in den drei Modulbereichen "Didaktik“, "Beratung“ und "Hochschule“ sowie begleitende Reflexionen in peer groups. Anschließend werden die Teilnehmenden in ein kollegiales Netzwerk überführt, das einem langfristigen Austausch dient und so die Nachhaltigkeit garantiert. Ziel des Angebotes ist es, insbesondere den vielen Mitarbeiter/inne/n im Qualitätspakt Lehre eine Möglichkeit der Professionalisierung zu geben, die im Aufbau befindlichen Strukturen zu verstetigen und damit eine nachhaltige Qualität der Angebote sicherzustellen. (DIPF/Orig.

The use of full-setting non-invasive ventilation in the home care of people with amyotrophic lateral sclerosis-motor neuron disease with end-stage respiratory muscle failure: a case series

<p>Abstract</p> <p>Introduction</p> <p>Little has been written about the use of non-invasive ventilation in the home care of amyotrophic lateral sclerosis-motor neuron disease patients with end-stage respiratory muscle failure. Nocturnal use of non-invasive ventilation has been reported to improve daytime blood gases but continuous non-invasive ventilation dependence has not been studied in this regard. There continues to be great variation by country, economics, physician interest and experience, local concepts of palliation, hospice requirements, and resources available for home care. We report a case series of home-based amyotrophic lateral sclerosis-motor neuron disease patients who refused tracheostomy and advanced non-invasive ventilation to full-setting, while maintaining normal alveolar ventilation and oxygenation in the course of the disease. Since this topic has been presented in only one center in the United States and nowhere else, it is appropriate to demonstrate that this can be done in other countries as well.</p> <p>Case presentation</p> <p>We present here the cases of three Caucasian patients (a 51-year-old Caucasian man, a 45-year-old Caucasian woman and a 57-year-old Caucasian woman) with amyotrophic lateral sclerosis who developed continuous non-invasive ventilation dependence for 15 to 27 months without major complications and were able to maintain normal CO₂and pulse oxyhemoglobin saturation despite a non-measurable vital capacity. All patients were wheelchair-dependent and receiving riluzole 50 mg twice a day. Patient one developed mild-to-moderate bulbar-innervated muscle weakness. He refused tracheostomy but accepted percutaneous gastrostomy. Patient two had two lung infections, acute bronchitis and pneumonia, which were treated with antibiotics and cough assistance at home. Patient three had three chest infections (bronchitis and pneumonias) and asthmatic episodes treated with antibiotics, bronchodilators and cough assistance at home. All patients had normal speech while receiving positive pressure; they died suddenly and with normal oxygen saturation.</p> <p>Conclusions</p> <p>Although warned that prognosis was poor as vital capacity diminished, our patients survived without invasive airway tubes and despite non-measurable vital capacity. No patient opted for tracheostomy. Our patients demonstrate the feasibility of resorting to full-setting non-invasive management to prolong survival, optimizing wellness and management at home, and the chance to die peacefully.</p

Quantifier scope in sentence prosody? : A view from production

Logical scope interpretation and sentence prosody exhibit intricate, yet scarcely studied interrelations across a variety of languages and constructions. Despite these observable interrelations, it is not clear whether quantifier scope by itself is able to directly affect prosodic form. Information structure is a key potential confounding factor, as it appears to richly interact both with scope interpretation and with prosodic form. To address this complication, the current study investigates, based on data from Hungarian, whether quantifier scope is expressed prosodically if information structure is kept in check. A production experiment is presented that investigates grammatically scope ambiguous doubly quantified sentences with varied focus structures, while lacking a syntactically marked topic or focus. In contrast to the information structural manipulation, which is manifest in the analysis of the acoustic data, the results reveal no prosodic effect of quantifier scope, nor the interaction of scope with information structure. This finding casts doubt on the notion that logical scope can receive direct prosodic expression, and it indirectly corroborates the restrictive view instead that scope interpretation is encoded in prosody only in cases in which it is a free rider on information structure